Projects
GEFOS
project name: Genetic Factors for Osteoporosis
initiating country: The European Union
Framework Programme: FP7 programme area: Health contract type: CP-FP – Collaborative Focused Research Project
contract/proposal/call number: 201865
status: active
start date: March 2008 duration: 48 months projected finish date: March 2012
Keywords
keywords: Healthcare delivery/services; Medicine; Health; osteoporosis; risk; genetics; statistics; populations
Project Budget
total budget: € 4,648,972
Participants
Note that the follow people may not represent the full extent of the consortium. FEAST has tried to identify the Australian participants, and their collaborators (or coordinator), within the project. Also note that Australian participation may not necessarily be on a formal level.
| name | organisation | state or country |
|---|---|---|
| Erasmus Universitair Medisch Centrum | The Netherlands | |
| Prof Matthew Brown | UQ | QLD, Australia |
Further information
summary:
Osteoporosis is a common, age-related disease with a strong genetic component. With increasing age of the population, Europe and industrialised countries across the globe are facing a substantial increase in osteoporotic fractures, which account for considerable disease-burden and costs. Early identification and treatment of subjects at risk can help preventing this, and genetic susceptibility alleles are the most promising risk factors in this respect. Large-scale prospective meta-analysis of individual gene polymorphisms in the EU-funded GENOMOS consortium was shown successful in identifying the expected subtle effects of gene polymorphisms which predispose to osteoporosis.
The recent development of powerful genome-wide genotyping technology now allows identifying -hypothesis free- strong and common genetic risk factors for complex diseases by Genome Wide Association (GWA) analysis. The AIM of the proposal is to identify osteoporosis susceptibility alleles by meta-analysis of GWA data obtained from a large collection of osteoporosis genetics cohorts in Europe and outside (n=46.000).
Source: European Commission
